Novartis has a collaboration with Intellia Therapeutics to use CRISPR gene editing to fix genetic mutations in blood stem cells. This included 14 years spent at Pfizer leading a team in the application of human genetics and computational biology to discover and develop therapeutics and pharmacogenomics strategies.The Company has also established a Scientific Advisory Board, and joining founder and SAB Chair, Dr. Chatterjee, the members include: Morton J. Cowen, M.D., pediatric immunologist, Professor Emeritus of Pediatrics and member of the Allergy, Immunology and Blood and Marrow Transplant Division in the Department of Pediatrics at UCSF Benioff Children’s Hospital; Stephen J. Elledge, Ph.D., Professor of Genetics at Harvard Medical School; Mason Freeman, M.D., Professor of Medicine at Harvard Medical School and Venture Partner at 5AM Ventures; Hans-Peter Kiem, M.D., Ph.D., Associate Head, Program in Transplantation Biology, Member, Clinical Research Division, Fred Hutchinson, Professor of Medicine / Adjunct Professor of Pathology University of Washington School of Medicine and Associate Head, Heme Malignancy Program, UW / Fred Hutchinson Cancer Center and Chair of the NIH RAC, the American Society for Gene and Cell Therapy (ASGCT) Stem Cell Committee, and the American Society of Hematology (ASH) Stem Cell and Regenerative Medicine Committee.In addition to Dr. Tzianabos, the Homology Board of Directors consists of Kush Parmar, M.D., Ph.D., Managing Partner at 5AM Ventures; Steven Gillis, Ph.D., Managing Director with ARCH Venture Partners, and Richard Gregory, Ph.D., Executive Vice President and Chief Scientific Officer of ImmunoGen.Sam Rasty, Ph.D., Chief Operating Officer, was Vice President and Head of New Products at the Rare Diseases Business Unit of Shire.
He spent nine years at Shire, where he played an active role in the development, approval, and commercial launch of multiple therapies for patients with rare genetic disorders, and worked closely with Business Development and Corporate Venture teams to invest in and acquire new companies and technologies. All rights reserved. Homology Medicines General Information Description. “The Company has an aggressive development plan and a significant opportunity to leapfrog current strategies in gene therapy and editing as it builds an expansive and high-value clinical pipeline.”Albert Seymour, Ph.D., Chief Scientific Officer, was the former Senior Vice President and Global Head of Research and Nonclinical Development at Shire. The DNA floats around until it is picked up to produce a healthy protein to treat a disease. To explore Homology Medicines‘s full profile, request access.
All Rights Reserved.If you have an ACS member number, please enter it here so we can link this account to your membership. Attention: Chief Innovation & Corporate Partnerships Officer . These arms encourage the natural process of homologous recombination, in which the old, mutant DNA flips out and the new DNA pops in. 1200 East California Boulevard . This approach requires the cells to be removed from a patient’s body, edited, and reinjected.Your account has been created successfully, and a confirmation email is on the way.Your username is now your ACS ID. Dr. Seymour brings more than 20 years of experience bridging Human Genetics with Pharmaceutical R&D, which resulted in the delivery of multiple therapeutic programs into development. Homology contends that varieties of AAV recently discovered in healthy human blood stem cells could be a game-changer, though, because of their high levels of uptake into the body compared with older versions, and their unique version of gene editing.Mickanin notes that Homology’s AAV system, unlike the popular CRISPR/Cas9 gene editing system, doesn’t need to cut DNA strands to replace old or insert new DNA. Homology Medicines, Inc. (Homology Medicines) is a pre-clinical stage biopharmaceutical company engaged in translating gene editing and gene therapy into novel treatment for patients suffering from rare genetic diseases. His career spans more than 20 years of scientific, clinical, commercial and business development experience in the life sciences across multiple specialty therapeutic areas, rare diseases and technology platforms. Homology is based on groundbreaking science that harnesses the naturally occurring process of homologous recombination. That could help avoid accidentally causing a new mutation during the repair process.Indeed, one focus of the Novartis-Homology partnership is genetic diseases affecting hemoglobin, of which sickle cell anemia is an example.
Prior to joining Shire, Dr. Rasty was responsible for Corporate Development and Strategic Marketing at Endo Pharmaceuticals, and Global Commercial Strategy and Portfolio Management at GlaxoSmithKline within the global research and development organization.Arthur Tzianabos, Ph.D., Chief Executive Officer and Director, has led teams in the discovery, development, clinical translation and commercialization of new treatments for serious diseases for over 25 years.
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