The drug is currently approved in over 80 countries worldwide and is used by over 600,000 patients, including patients using the drug for indications other than RA. The combined Phase I/II studies will aim to deliver the vaccine to a total of 300 people at sites across the UK……..There are no obvious criteria that would determine whether a country is handling COVID-19 good or not.From Derek’s summary on Pfizer: “Recall that this effort actually has four different mRNA vaccine programs: two with modified RNA bases, one with extra uridine bases, and one in the “self-amplifying” category.”That was a complex enough issue that someone else’s reporting macro for generating adverse events was reporting those events is a noticeably wrong order (the dataset was small enough to make that obvious). ** Tyrosine kinase is related to autoimmune diseases, such as RA, and plays a key role in signaling related to cell growth and differentiation (tyrosine kinase: an enzyme which adds phosphoric acid to tyrosine, one of amino acids that make up proteins) In this scenario, challenge trials are bad because they risk showing quickly that some of their approaches don’t work very well and they need to string us along until the Chinese save the world and they can go back to doing the stuff that is actually in their financial interest. Patients are being handled with airborne precautions, though (N95 or respirator, eye protection, gown, gloves).Any idea why the mRNA trials involve such a small sample? Pretty much everyone reported it after the second, which is to be expected. You can’t just jab anybody (at the moment, anyway)That’s true, I was just thinking more in terms of just how many people we could dose as we ramp up production (double the amount of doses needed=half the people dosed).Depends on age, I’m too young to have had a smallpox vaccine but just old enough for the BCG vaccine for TB (before routine use in the UK was stopped) and the distinctive upper arm scar. Yes, it leaves a scar.New Zealand probably can’t sustain its economy with indefinite quarantine from the rest of the world, but if a vaccine comes along early next year, their plan will have worked great.Maybe logistical wasn’t the right wordIf you add funny animals, a queen and a horrible accent to the US you get Australia – I am not sure the lack of a king/queen is the radically different governmental structure you had in mind.One thing that caught my eye in this post was the comment about measuring neutralizing antibodies from patient samples. We are committed to delivering high quality medicines and believe this agreement will help us accelerate our ability to achieve our vision: Transform the Japanese Healthcare Environment with Established Products by 2020." One hopes that several of these efforts succeed and the strategy for the most optimal vaccines emerge from the data.Of course, we’d expect that decent antibody levels should be good, but we’re still guessing. Seeing some early promising results but not sure of the science.Interesting article.
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